Degenerative disc disease is typically treated with NSAIDs and chiropractic or physical therapy mobilization. Smoking cessation and strengthening also help treat this disorder. Facet steroid injections provide indirect relief and for select cases,intradiscal steroid injection may provide direct relief. Refractory cases may benefit from diagnostic discography followed by artificial disc replacement in the cervical spine and MIS-TLIF in the lumbar spine. Mesenchymal stem cell therapy is an alternative band-aid regenerative technique.